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Istradefylline 40 mg/working day greater peak amounts and AUC of CYP3A4 substrates in medical trials. This impact wasn't noticed with istradefylline twenty mg/working day. Take into consideration dose reduction of delicate CYP3A4 substrates.darifenacin will boost the stage or impact of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metab